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Once STAT reaches the nucleus, it binds to a consensus DNA-recognition motif called gamma-activated sites (GAS) in the promoter region of cytokine-inducible genes and activates transcription. The STAT protein can be dephosphorylated by nuclear phosphatases , which leads to inactivation of STAT and subsequent transport out of the nucleus by an exportin - RanGTP complex.

STAT Events; Industry Events Calendar; 2021 STAT Health Tech Summit; 2021 STAT Breakthrough Science Summit; Webinars. Newsletters; Reports; Video; Podcasts. The Readout LOUD; First Opinion Podcast STAT Gene Family Signal transducer and activator of transcription (STAT) proteins comprise a family of transcription factors that are activated by hormones, cytokines and growth factors. The activation of STAT proteins plays an important role in the production of mature hematopoietic cells via effects on cellular proliferation, survival and lineage-specific differentiation. Aperçu, en quelques mots. Notre groupe mène des projets de recherche scientifique dans le domaine de l'épidémiologie génétique. Nous développons et appliquons des modèles de statistiques de génétiques et des outils bioinformatiques dans le cadre d'études cliniques sur les maladies cardiovasculaires et métaboliques, et sur l'efficacité et la sécurité des médicaments.

Stat gene

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The STAT3 gene encodes a transcription factor that plays a critical role in mediating cytokine-induced changes in gene expression. Following activation, members of the STAT family translocate to the nucleus and interact with specific DNA elements (summary by Milner et al., 2015). ▼ Cloning and Expression 2002-05-01 · As reviewed elsewhere in this Perspective series, the analysis of mice lacking one or more Stat genes has shown relatively discrete phenotypes, assigning each Stat protein to a relatively specific pathway. Not so with Stat3.

Fil:Stat scb 2.JPG |Source=Own work by uploader |Author=Krokodilkalle |Date=2008-10-19 |Permission={{GFDL}} |other_versions= }} Statistics graph gene 

The STAT3 gene encodes signal transducer and activator of transcription 3, also known as acute-phase response factor (APRF). STAT3 is a transcriptional activator that is induced by various cytokines and growth factors, and is involved in a wide range of physiological processes including embryonic development, immunity, and cancer. GeneCards Summary for STATH Gene STATH (Statherin) is a Protein Coding gene.

Stat gene

On unicorns and genes Evolution, or depending on edition, Gene Editing and the Unthinkable Power to Control Evolution. Stat News. 2018 

Mutations of the genes encoding for STAT1, -2, -3, and -5b impair their   STAT protein The Signal Transducers and Activator of Transcription (STAT, also, IRF9 (Interferon Response Factor) to form ISGF3 (Interferon Stimulated Gene  Members of the signal transducer and activator of transcription (STAT) protein family Gene knockout studies have provided evidence that STAT proteins are  Here, we have used genome-wide microarrays to identify JAK/STAT targets in the optic lobes of the Drosophila brain and identified 47 genes that are positively  Experiments were usually complete multi-factorial designs (genetic x management), replicated in randomised blocks usually with some split plotting.

Stat gene

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Unlike all other members of the Stat gene family, ablation of Stat3 leads to embryonic lethality .
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The STAT1 gene is associated with autosomal recessive STAT1 deficiency (MedGen UID: 462438), autosomal dominant Mendelian susceptibility to mycobacterial disease (MedGen UID: 862387), and autosomal dominant STAT1 gain-of-function associated chronic mucocutaneous candidiasis (MedGen UID: 481620).

The STAT protein can be dephosphorylated by nuclear phosphatases , which leads to inactivation of STAT and subsequent transport out of the nucleus by an exportin - RanGTP complex. signal transducer and activator of transcription 1, 91kDa|The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The gene view histogram is a graphical view of mutations across STAT3.


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Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Interferon Regulatory Factors > Interferon-Stimulated Gene Factor 3, gamma Subunit.

They respond to cytokines and growth factors and act as transcription activators. It mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens . Mutations in this gene can cause immunodeficiency . STAT1 phosphorylation, dimerization, and translocation to the nucleus will induce target gene transcription and expression.

General information; Gene symbol: STAT1: Gene name: signal transducer and activator of transcription 1, 91kDa: Chromosome: 2: Chromosomal band: q32.2-q32.3: Imprinted

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Gene target information for STAT3 - signal transducer and activator of transcription 3 (human).

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